Synthesis of trifunctional cyclo-β-tripeptide templates

• Frank Stein,
• Tahir Mehmood,
• Tilman Plass,
• Javid H. Zaidi and
• Ulf Diederichsen

Beilstein J. Org. Chem. 2012, 8, 1576–1583, doi:10.3762/bjoc.8.180

• The concept of template-assembled synthetic proteins (TASP) describes a central scaffold that predefines the three dimensional structure for diverse molecules linked to this platform. Cyclic β-tripeptides are interesting candidates for use as templates due to their conformationally defined structure

• ; cyclic β-tripeptide scaffold; orthogonal protection groups; peptide synthesis; template-assembled synthetic proteins (TASP); Introduction Cyclic β-tripeptides form structurally well-defined secondary structures with the potential for alignment of the rings to form intermolecular aggregates [1]. Due to

• cyclic β-tripeptides interesting candidates for the concept of template-assembled synthetic proteins (TASP) [5][6]. The TASP concept describes a central scaffolding molecule directing all further attached molecules into a spatially predefined structure. Cyclic β-tripeptides are suitable for use as a